Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-l...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
BMC
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c48cc67a29084172b104624fff504bb1 |
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| Sumario: | Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-loading with phenformin and ICG named ICG@PM@NP was constructed by modified two-step biomineralization method. ICG@PM@NP could enhance T cell infiltration and antitumor metastasis in vivo. ICG@PM@NP mediated mild-photothermal therapy could make up the defects of conventional mild-photothermal therapy in lacking the anti-metastasis ability and inducing enhanced PD-L1 expression. |
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