Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-l...

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Autores principales:	Zaigang Zhou, Ning Jiang, Jiashe Chen, Chunjuan Zheng, Yuanyuan Guo, Ruirong Ye, Ruogu Qi, Jianliang Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mitochondrial inhibition Mild-temperature photothermal therapy Programmed cell death-ligand 1 Biomineralization Tumor metastasis Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/c48cc67a29084172b104624fff504bb1
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spelling	oai:doaj.org-article:c48cc67a29084172b104624fff504bb12021-11-21T12:29:37ZSelectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy10.1186/s12951-021-01124-81477-3155https://doaj.org/article/c48cc67a29084172b104624fff504bb12021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01124-8https://doaj.org/toc/1477-3155Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-loading with phenformin and ICG named ICG@PM@NP was constructed by modified two-step biomineralization method. ICG@PM@NP could enhance T cell infiltration and antitumor metastasis in vivo. ICG@PM@NP mediated mild-photothermal therapy could make up the defects of conventional mild-photothermal therapy in lacking the anti-metastasis ability and inducing enhanced PD-L1 expression.Zaigang ZhouNing JiangJiashe ChenChunjuan ZhengYuanyuan GuoRuirong YeRuogu QiJianliang ShenBMCarticleMitochondrial inhibitionMild-temperature photothermal therapyProgrammed cell death-ligand 1BiomineralizationTumor metastasisBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mitochondrial inhibition Mild-temperature photothermal therapy Programmed cell death-ligand 1 Biomineralization Tumor metastasis Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Mitochondrial inhibition Mild-temperature photothermal therapy Programmed cell death-ligand 1 Biomineralization Tumor metastasis Biotechnology TP248.13-248.65 Medical technology R855-855.5 Zaigang Zhou Ning Jiang Jiashe Chen Chunjuan Zheng Yuanyuan Guo Ruirong Ye Ruogu Qi Jianliang Shen Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
description	Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-loading with phenformin and ICG named ICG@PM@NP was constructed by modified two-step biomineralization method. ICG@PM@NP could enhance T cell infiltration and antitumor metastasis in vivo. ICG@PM@NP mediated mild-photothermal therapy could make up the defects of conventional mild-photothermal therapy in lacking the anti-metastasis ability and inducing enhanced PD-L1 expression.
format	article
author	Zaigang Zhou Ning Jiang Jiashe Chen Chunjuan Zheng Yuanyuan Guo Ruirong Ye Ruogu Qi Jianliang Shen
author_facet	Zaigang Zhou Ning Jiang Jiashe Chen Chunjuan Zheng Yuanyuan Guo Ruirong Ye Ruogu Qi Jianliang Shen
author_sort	Zaigang Zhou
title	Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
title_short	Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
title_full	Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
title_fullStr	Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
title_full_unstemmed	Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
title_sort	selectively down-regulated pd-l1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c48cc67a29084172b104624fff504bb1
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Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

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