CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

CDK5 is known to drive glioblastoma tumorigenicity but the downstream molecular mechanism is unknown. Here, the authors show that CDK5 activates STAT3 signalling via the nuclear import of TRIM59, which leads to the degradation of the tumour suppressor macroH2A1.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Youzhou Sang, Yanxin Li, Yingwen Zhang, Angel A. Alvarez, Bo Yu, Weiwei Zhang, Bo Hu, Shi-Yuan Cheng, Haizhong Feng
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Q
Accès en ligne:https://doaj.org/article/c4a497b4b1e04bd3908f0826fd4ebcfd
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!