CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

CDK5 is known to drive glioblastoma tumorigenicity but the downstream molecular mechanism is unknown. Here, the authors show that CDK5 activates STAT3 signalling via the nuclear import of TRIM59, which leads to the degradation of the tumour suppressor macroH2A1.

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Autores principales:	Youzhou Sang, Yanxin Li, Yingwen Zhang, Angel A. Alvarez, Bo Yu, Weiwei Zhang, Bo Hu, Shi-Yuan Cheng, Haizhong Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4a497b4b1e04bd3908f0826fd4ebcfd
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spelling	oai:doaj.org-article:c4a497b4b1e04bd3908f0826fd4ebcfd2021-12-02T15:35:48ZCDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity10.1038/s41467-019-12001-22041-1723https://doaj.org/article/c4a497b4b1e04bd3908f0826fd4ebcfd2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12001-2https://doaj.org/toc/2041-1723CDK5 is known to drive glioblastoma tumorigenicity but the downstream molecular mechanism is unknown. Here, the authors show that CDK5 activates STAT3 signalling via the nuclear import of TRIM59, which leads to the degradation of the tumour suppressor macroH2A1.Youzhou SangYanxin LiYingwen ZhangAngel A. AlvarezBo YuWeiwei ZhangBo HuShi-Yuan ChengHaizhong FengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youzhou Sang Yanxin Li Yingwen Zhang Angel A. Alvarez Bo Yu Weiwei Zhang Bo Hu Shi-Yuan Cheng Haizhong Feng CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
description	CDK5 is known to drive glioblastoma tumorigenicity but the downstream molecular mechanism is unknown. Here, the authors show that CDK5 activates STAT3 signalling via the nuclear import of TRIM59, which leads to the degradation of the tumour suppressor macroH2A1.
format	article
author	Youzhou Sang Yanxin Li Yingwen Zhang Angel A. Alvarez Bo Yu Weiwei Zhang Bo Hu Shi-Yuan Cheng Haizhong Feng
author_facet	Youzhou Sang Yanxin Li Yingwen Zhang Angel A. Alvarez Bo Yu Weiwei Zhang Bo Hu Shi-Yuan Cheng Haizhong Feng
author_sort	Youzhou Sang
title	CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
title_short	CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
title_full	CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
title_fullStr	CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
title_full_unstemmed	CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
title_sort	cdk5-dependent phosphorylation and nuclear translocation of trim59 promotes macroh2a1 ubiquitination and tumorigenicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c4a497b4b1e04bd3908f0826fd4ebcfd
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CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

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