nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse

nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse

Abstract An evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD. Astrogliosis was observed in cortex and hippocampus, with cellular...

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Main Authors: D’Angelo Chiara, Costantini Erica, Salvador Nieves, Marchioni Michele, Di Nicola Marta, Greig H. Nigel, Reale Marcella
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c4aad8a0c7404052a401dc4f37a93ef6
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