Tumour gene expression signature in primary melanoma predicts long-term outcomes

The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop and validate a 121 metastasis-associated gene sign...

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Autores principales:	Manik Garg, Dominique-Laurent Couturier, Jérémie Nsengimana, Nuno A. Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Göran B. Jönsson, Julia Newton-Bishop, Christine Parkinson, Mark R. Middleton, D. Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A. Vergara, Serigne Lo, Felicity Newell, James S. Wilmott, John F. Thompson, Georgina V. Long, Richard A. Scolyer, Pippa Corrie, David J. Adams, Alvis Brazma, Roy Rabbie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4c725539da241dab371faec795d6af6
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spelling	oai:doaj.org-article:c4c725539da241dab371faec795d6af62021-12-02T14:21:30ZTumour gene expression signature in primary melanoma predicts long-term outcomes10.1038/s41467-021-21207-22041-1723https://doaj.org/article/c4c725539da241dab371faec795d6af62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21207-2https://doaj.org/toc/2041-1723The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop and validate a 121 metastasis-associated gene signature identifying early-stage melanoma patients at higher risk of metastasis and worse survival.Manik GargDominique-Laurent CouturierJérémie NsengimanaNuno A. FonsecaMatthew WongchenkoYibing YanMartin LaussGöran B. JönssonJulia Newton-BishopChristine ParkinsonMark R. MiddletonD. Timothy BishopSarah McDonaldNikki StefanosJohn TadrossIsmael A. VergaraSerigne LoFelicity NewellJames S. WilmottJohn F. ThompsonGeorgina V. LongRichard A. ScolyerPippa CorrieDavid J. AdamsAlvis BrazmaRoy RabbieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manik Garg Dominique-Laurent Couturier Jérémie Nsengimana Nuno A. Fonseca Matthew Wongchenko Yibing Yan Martin Lauss Göran B. Jönsson Julia Newton-Bishop Christine Parkinson Mark R. Middleton D. Timothy Bishop Sarah McDonald Nikki Stefanos John Tadross Ismael A. Vergara Serigne Lo Felicity Newell James S. Wilmott John F. Thompson Georgina V. Long Richard A. Scolyer Pippa Corrie David J. Adams Alvis Brazma Roy Rabbie Tumour gene expression signature in primary melanoma predicts long-term outcomes
description	The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop and validate a 121 metastasis-associated gene signature identifying early-stage melanoma patients at higher risk of metastasis and worse survival.
format	article
author	Manik Garg Dominique-Laurent Couturier Jérémie Nsengimana Nuno A. Fonseca Matthew Wongchenko Yibing Yan Martin Lauss Göran B. Jönsson Julia Newton-Bishop Christine Parkinson Mark R. Middleton D. Timothy Bishop Sarah McDonald Nikki Stefanos John Tadross Ismael A. Vergara Serigne Lo Felicity Newell James S. Wilmott John F. Thompson Georgina V. Long Richard A. Scolyer Pippa Corrie David J. Adams Alvis Brazma Roy Rabbie
author_facet	Manik Garg Dominique-Laurent Couturier Jérémie Nsengimana Nuno A. Fonseca Matthew Wongchenko Yibing Yan Martin Lauss Göran B. Jönsson Julia Newton-Bishop Christine Parkinson Mark R. Middleton D. Timothy Bishop Sarah McDonald Nikki Stefanos John Tadross Ismael A. Vergara Serigne Lo Felicity Newell James S. Wilmott John F. Thompson Georgina V. Long Richard A. Scolyer Pippa Corrie David J. Adams Alvis Brazma Roy Rabbie
author_sort	Manik Garg
title	Tumour gene expression signature in primary melanoma predicts long-term outcomes
title_short	Tumour gene expression signature in primary melanoma predicts long-term outcomes
title_full	Tumour gene expression signature in primary melanoma predicts long-term outcomes
title_fullStr	Tumour gene expression signature in primary melanoma predicts long-term outcomes
title_full_unstemmed	Tumour gene expression signature in primary melanoma predicts long-term outcomes
title_sort	tumour gene expression signature in primary melanoma predicts long-term outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4c725539da241dab371faec795d6af6
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Tumour gene expression signature in primary melanoma predicts long-term outcomes

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