Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins.

Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins.

Nesprin-1 and nesprin-2 are nuclear envelope (NE) proteins characterized by a common structure of an SR (spectrin repeat) rod domain and a C-terminal transmembrane KASH [Klarsicht-ANC-Syne-homology] domain and display N-terminal actin-binding CH (calponin homology) domains. Mutations in these protei...

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Main Authors: Flavia Autore, Mark Pfuhl, Xueping Quan, Aisling Williams, Roland G Roberts, Catherine M Shanahan, Franca Fraternali
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c4d82715b36b4818a5bfc3da7917e11c
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