Extracellular cap domain is an essential component of the TRPV1 gating mechanism

Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV1 conductance and ion selectivity.

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Autores principales: Kirill D. Nadezhdin, Arthur Neuberger, Yury A. Nikolaev, Lyle A. Murphy, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c
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