Extracellular cap domain is an essential component of the TRPV1 gating mechanism

Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV1 conductance and ion selectivity.

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Autores principales:	Kirill D. Nadezhdin, Arthur Neuberger, Yury A. Nikolaev, Lyle A. Murphy, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c
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spelling	oai:doaj.org-article:c4fde09e03ba45fbaf81d692cd390f1c2021-12-02T15:51:07ZExtracellular cap domain is an essential component of the TRPV1 gating mechanism10.1038/s41467-021-22507-32041-1723https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22507-3https://doaj.org/toc/2041-1723Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV1 conductance and ion selectivity.Kirill D. NadezhdinArthur NeubergerYury A. NikolaevLyle A. MurphyElena O. GrachevaSviatoslav N. BagriantsevAlexander I. SobolevskyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kirill D. Nadezhdin Arthur Neuberger Yury A. Nikolaev Lyle A. Murphy Elena O. Gracheva Sviatoslav N. Bagriantsev Alexander I. Sobolevsky Extracellular cap domain is an essential component of the TRPV1 gating mechanism
description	Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV1 conductance and ion selectivity.
format	article
author	Kirill D. Nadezhdin Arthur Neuberger Yury A. Nikolaev Lyle A. Murphy Elena O. Gracheva Sviatoslav N. Bagriantsev Alexander I. Sobolevsky
author_facet	Kirill D. Nadezhdin Arthur Neuberger Yury A. Nikolaev Lyle A. Murphy Elena O. Gracheva Sviatoslav N. Bagriantsev Alexander I. Sobolevsky
author_sort	Kirill D. Nadezhdin
title	Extracellular cap domain is an essential component of the TRPV1 gating mechanism
title_short	Extracellular cap domain is an essential component of the TRPV1 gating mechanism
title_full	Extracellular cap domain is an essential component of the TRPV1 gating mechanism
title_fullStr	Extracellular cap domain is an essential component of the TRPV1 gating mechanism
title_full_unstemmed	Extracellular cap domain is an essential component of the TRPV1 gating mechanism
title_sort	extracellular cap domain is an essential component of the trpv1 gating mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4fde09e03ba45fbaf81d692cd390f1c
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Extracellular cap domain is an essential component of the TRPV1 gating mechanism

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