LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.

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Auteurs principaux: Hamed Yari, Lei Jin, Liu Teng, Yufang Wang, Yongyan Wu, Guang Zhi Liu, Wei Gao, Jin Liang, Yanfeng Xi, Yu Chen Feng, Chunming Zhang, Yuan Yuan Zhang, Hessam Tabatabaee, Ting La, Rui Hong Yang, Fu Hua Wang, Xu Guang Yan, Margaret Farrelly, Rodney Scott, Tao Liu, Rick F. Thorne, Su Tang Guo, Xu Dong Zhang
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/c55d93947a734bacbb45ea1a22e7ea16
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