ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

Abstract Background Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes. Urea metabolism is one such altered pathway in ccRCC. The aim of this study was to elucidate...

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Autores principales: Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith, M. Celeste Simon
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
ccRCC
Urea cycle
Argininosuccinate synthase 1
Argininosuccinate lyase
Aspartate
DNA synthesis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/c58358261d474004af1c1f7c4c61d199
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https://doaj.org/article/c58358261d474004af1c1f7c4c61d199

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