Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs

Abstract A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide...

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Autores principales:	Bryan C. Nikolai, Prashi Jain, David L. Cardenas, Brian York, Qin Feng, Neil J. McKenna, Subhamoy Dasgupta, David M. Lonard, Bert W. O’Malley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5aa049a9d6547ecb096ffd0b12d8bba
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spelling	oai:doaj.org-article:c5aa049a9d6547ecb096ffd0b12d8bba2021-12-02T14:11:29ZSteroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs10.1038/s41598-021-82945-32045-2322https://doaj.org/article/c5aa049a9d6547ecb096ffd0b12d8bba2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82945-3https://doaj.org/toc/2045-2322Abstract A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide variety of cell types. Src-3 knockout mice display broad lymphoproliferation and hypersensitivity to systemic inflammation. Using publicly available bioinformatics data and directed cellular approaches, we show that SRC-3 also is highly enriched in Tregs in mice and humans. Human Tregs lose phenotypic characteristics when SRC-3 is depleted or pharmacologically inhibited, including failure of induction from resting T cells and loss of the ability to suppress proliferation of stimulated T cells. These data support a model for SRC-3 as a coactivator that actively participates in protection from autoimmunity and may support immune evasion of cancers by contributing to the biology of Tregs.Bryan C. NikolaiPrashi JainDavid L. CardenasBrian YorkQin FengNeil J. McKennaSubhamoy DasguptaDavid M. LonardBert W. O’MalleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryan C. Nikolai Prashi Jain David L. Cardenas Brian York Qin Feng Neil J. McKenna Subhamoy Dasgupta David M. Lonard Bert W. O’Malley Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
description	Abstract A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide variety of cell types. Src-3 knockout mice display broad lymphoproliferation and hypersensitivity to systemic inflammation. Using publicly available bioinformatics data and directed cellular approaches, we show that SRC-3 also is highly enriched in Tregs in mice and humans. Human Tregs lose phenotypic characteristics when SRC-3 is depleted or pharmacologically inhibited, including failure of induction from resting T cells and loss of the ability to suppress proliferation of stimulated T cells. These data support a model for SRC-3 as a coactivator that actively participates in protection from autoimmunity and may support immune evasion of cancers by contributing to the biology of Tregs.
format	article
author	Bryan C. Nikolai Prashi Jain David L. Cardenas Brian York Qin Feng Neil J. McKenna Subhamoy Dasgupta David M. Lonard Bert W. O’Malley
author_facet	Bryan C. Nikolai Prashi Jain David L. Cardenas Brian York Qin Feng Neil J. McKenna Subhamoy Dasgupta David M. Lonard Bert W. O’Malley
author_sort	Bryan C. Nikolai
title	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
title_short	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
title_full	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
title_fullStr	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
title_full_unstemmed	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
title_sort	steroid receptor coactivator 3 (src-3/aib1) is enriched and functional in mouse and human tregs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5aa049a9d6547ecb096ffd0b12d8bba
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Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs

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