Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

Synovial fibroblasts are thought to be central mediators of joint destruction in rheumatoid arthritis (RA). Here the authors use single-cell transcriptomics and flow cytometry to identify synovial fibroblast subsets that are expanded and display distinct tissue distribution and function in patients...

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Autores principales:	Fumitaka Mizoguchi, Kamil Slowikowski, Kevin Wei, Jennifer L. Marshall, Deepak A. Rao, Sook Kyung Chang, Hung N. Nguyen, Erika H. Noss, Jason D. Turner, Brandon E. Earp, Philip E. Blazar, John Wright, Barry P. Simmons, Laura T. Donlin, George D. Kalliolias, Susan M. Goodman, Vivian P. Bykerk, Lionel B. Ivashkiv, James A. Lederer, Nir Hacohen, Peter A. Nigrovic, Andrew Filer, Christopher D. Buckley, Soumya Raychaudhuri, Michael B. Brenner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5ce4a229b2441f988b5517aa170745b
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spelling	oai:doaj.org-article:c5ce4a229b2441f988b5517aa170745b2021-12-02T17:32:30ZFunctionally distinct disease-associated fibroblast subsets in rheumatoid arthritis10.1038/s41467-018-02892-y2041-1723https://doaj.org/article/c5ce4a229b2441f988b5517aa170745b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02892-yhttps://doaj.org/toc/2041-1723Synovial fibroblasts are thought to be central mediators of joint destruction in rheumatoid arthritis (RA). Here the authors use single-cell transcriptomics and flow cytometry to identify synovial fibroblast subsets that are expanded and display distinct tissue distribution and function in patients with RA.Fumitaka MizoguchiKamil SlowikowskiKevin WeiJennifer L. MarshallDeepak A. RaoSook Kyung ChangHung N. NguyenErika H. NossJason D. TurnerBrandon E. EarpPhilip E. BlazarJohn WrightBarry P. SimmonsLaura T. DonlinGeorge D. KallioliasSusan M. GoodmanVivian P. BykerkLionel B. IvashkivJames A. LedererNir HacohenPeter A. NigrovicAndrew FilerChristopher D. BuckleySoumya RaychaudhuriMichael B. BrennerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fumitaka Mizoguchi Kamil Slowikowski Kevin Wei Jennifer L. Marshall Deepak A. Rao Sook Kyung Chang Hung N. Nguyen Erika H. Noss Jason D. Turner Brandon E. Earp Philip E. Blazar John Wright Barry P. Simmons Laura T. Donlin George D. Kalliolias Susan M. Goodman Vivian P. Bykerk Lionel B. Ivashkiv James A. Lederer Nir Hacohen Peter A. Nigrovic Andrew Filer Christopher D. Buckley Soumya Raychaudhuri Michael B. Brenner Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
description	Synovial fibroblasts are thought to be central mediators of joint destruction in rheumatoid arthritis (RA). Here the authors use single-cell transcriptomics and flow cytometry to identify synovial fibroblast subsets that are expanded and display distinct tissue distribution and function in patients with RA.
format	article
author	Fumitaka Mizoguchi Kamil Slowikowski Kevin Wei Jennifer L. Marshall Deepak A. Rao Sook Kyung Chang Hung N. Nguyen Erika H. Noss Jason D. Turner Brandon E. Earp Philip E. Blazar John Wright Barry P. Simmons Laura T. Donlin George D. Kalliolias Susan M. Goodman Vivian P. Bykerk Lionel B. Ivashkiv James A. Lederer Nir Hacohen Peter A. Nigrovic Andrew Filer Christopher D. Buckley Soumya Raychaudhuri Michael B. Brenner
author_facet	Fumitaka Mizoguchi Kamil Slowikowski Kevin Wei Jennifer L. Marshall Deepak A. Rao Sook Kyung Chang Hung N. Nguyen Erika H. Noss Jason D. Turner Brandon E. Earp Philip E. Blazar John Wright Barry P. Simmons Laura T. Donlin George D. Kalliolias Susan M. Goodman Vivian P. Bykerk Lionel B. Ivashkiv James A. Lederer Nir Hacohen Peter A. Nigrovic Andrew Filer Christopher D. Buckley Soumya Raychaudhuri Michael B. Brenner
author_sort	Fumitaka Mizoguchi
title	Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
title_short	Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
title_full	Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
title_fullStr	Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
title_full_unstemmed	Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
title_sort	functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c5ce4a229b2441f988b5517aa170745b
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Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

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