Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Here, the authors analyse the distance between the body of an antibody and a protein antigen denoted as the Antibody-Framework-to-Antigen Distance (AFAD) for about 2000 non-redundant antibody-protein antigen complexes in the Protein Data Bank. They observe that antibodies with exceptionally long AFA...

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Autores principales:	Myungjin Lee, Anita Changela, Jason Gorman, Reda Rawi, Tatsiana Bylund, Cara W. Chao, Bob C. Lin, Mark K. Louder, Adam S. Olia, Baoshan Zhang, Nicole A. Doria-Rose, Susan Zolla-Pazner, Lawrence Shapiro, Gwo-Yu Chuang, Peter D. Kwong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6314cb8177848269383e9f05a200718
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spelling	oai:doaj.org-article:c6314cb8177848269383e9f05a2007182021-11-14T12:36:39ZExtended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces10.1038/s41467-021-26579-z2041-1723https://doaj.org/article/c6314cb8177848269383e9f05a2007182021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26579-zhttps://doaj.org/toc/2041-1723Here, the authors analyse the distance between the body of an antibody and a protein antigen denoted as the Antibody-Framework-to-Antigen Distance (AFAD) for about 2000 non-redundant antibody-protein antigen complexes in the Protein Data Bank. They observe that antibodies with exceptionally long AFADs were all broad HIV-1-neutralizing antibodies that targeted densely glycosylated regions on the HIV-1-envelope trimer. The connection between long AFAD and dense glycan was further validated by the cryo-EM structure of antibody 2909 recognizing a glycan hole and by glycan shielding analyses based on molecular dynamics simulations.Myungjin LeeAnita ChangelaJason GormanReda RawiTatsiana BylundCara W. ChaoBob C. LinMark K. LouderAdam S. OliaBaoshan ZhangNicole A. Doria-RoseSusan Zolla-PaznerLawrence ShapiroGwo-Yu ChuangPeter D. KwongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myungjin Lee Anita Changela Jason Gorman Reda Rawi Tatsiana Bylund Cara W. Chao Bob C. Lin Mark K. Louder Adam S. Olia Baoshan Zhang Nicole A. Doria-Rose Susan Zolla-Pazner Lawrence Shapiro Gwo-Yu Chuang Peter D. Kwong Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
description	Here, the authors analyse the distance between the body of an antibody and a protein antigen denoted as the Antibody-Framework-to-Antigen Distance (AFAD) for about 2000 non-redundant antibody-protein antigen complexes in the Protein Data Bank. They observe that antibodies with exceptionally long AFADs were all broad HIV-1-neutralizing antibodies that targeted densely glycosylated regions on the HIV-1-envelope trimer. The connection between long AFAD and dense glycan was further validated by the cryo-EM structure of antibody 2909 recognizing a glycan hole and by glycan shielding analyses based on molecular dynamics simulations.
format	article
author	Myungjin Lee Anita Changela Jason Gorman Reda Rawi Tatsiana Bylund Cara W. Chao Bob C. Lin Mark K. Louder Adam S. Olia Baoshan Zhang Nicole A. Doria-Rose Susan Zolla-Pazner Lawrence Shapiro Gwo-Yu Chuang Peter D. Kwong
author_facet	Myungjin Lee Anita Changela Jason Gorman Reda Rawi Tatsiana Bylund Cara W. Chao Bob C. Lin Mark K. Louder Adam S. Olia Baoshan Zhang Nicole A. Doria-Rose Susan Zolla-Pazner Lawrence Shapiro Gwo-Yu Chuang Peter D. Kwong
author_sort	Myungjin Lee
title	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
title_short	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
title_full	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
title_fullStr	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
title_full_unstemmed	Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces
title_sort	extended antibody-framework-to-antigen distance observed exclusively with broad hiv-1-neutralizing antibodies recognizing glycan-dense surfaces
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6314cb8177848269383e9f05a200718
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Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

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