Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Here, the authors analyse the distance between the body of an antibody and a protein antigen denoted as the Antibody-Framework-to-Antigen Distance (AFAD) for about 2000 non-redundant antibody-protein antigen complexes in the Protein Data Bank. They observe that antibodies with exceptionally long AFA...

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Autores principales: Myungjin Lee, Anita Changela, Jason Gorman, Reda Rawi, Tatsiana Bylund, Cara W. Chao, Bob C. Lin, Mark K. Louder, Adam S. Olia, Baoshan Zhang, Nicole A. Doria-Rose, Susan Zolla-Pazner, Lawrence Shapiro, Gwo-Yu Chuang, Peter D. Kwong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c6314cb8177848269383e9f05a200718
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