Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent modification of thiol-containing target proteins. The cytoprotective, anti-inflammatory, and anti-tumorigenic effects of NFA in animal models of disea...

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Autores principales: Nadine Hellmuth, Camilla Brat, Omar Awad, Sven George, Astrid Kahnt, Tom Bauer, Hai Phong Huynh Phuoc, Dieter Steinhilber, Carlo Angioni, Mohamed Hassan, Katharina J. Hock, Georg Manolikakes, Kai Zacharowski, Jessica Roos, Thorsten J. Maier
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
nitroalkene
michael acceptor
structure-function
NF-κB
soluble epoxide hydrolase
Nrf-2, 5-lipoxygenase
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/c657c0db8df64313911506d3687aff34
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https://doaj.org/article/c657c0db8df64313911506d3687aff34

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