E47 modulates hepatic glucocorticoid action

Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglyc...

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Bibliographic Details
Main Authors: M. Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M. Evans, N. Henriette Uhlenhaut
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e
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