E47 modulates hepatic glucocorticoid action
Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglyc...
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Nature Portfolio
2019
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oai:doaj.org-article:c66a0d65c60642e39dc4efc1ae62484e2021-12-02T15:35:33ZE47 modulates hepatic glucocorticoid action10.1038/s41467-018-08196-52041-1723https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08196-5https://doaj.org/toc/2041-1723Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.M. Charlotte HemmerMichael WiererKristina SchachtrupMichael DownesNorbert HübnerRonald M. EvansN. Henriette UhlenhautNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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Science Q M. Charlotte Hemmer Michael Wierer Kristina Schachtrup Michael Downes Norbert Hübner Ronald M. Evans N. Henriette Uhlenhaut E47 modulates hepatic glucocorticoid action |
description |
Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs. |
format |
article |
author |
M. Charlotte Hemmer Michael Wierer Kristina Schachtrup Michael Downes Norbert Hübner Ronald M. Evans N. Henriette Uhlenhaut |
author_facet |
M. Charlotte Hemmer Michael Wierer Kristina Schachtrup Michael Downes Norbert Hübner Ronald M. Evans N. Henriette Uhlenhaut |
author_sort |
M. Charlotte Hemmer |
title |
E47 modulates hepatic glucocorticoid action |
title_short |
E47 modulates hepatic glucocorticoid action |
title_full |
E47 modulates hepatic glucocorticoid action |
title_fullStr |
E47 modulates hepatic glucocorticoid action |
title_full_unstemmed |
E47 modulates hepatic glucocorticoid action |
title_sort |
e47 modulates hepatic glucocorticoid action |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e |
work_keys_str_mv |
AT mcharlottehemmer e47modulateshepaticglucocorticoidaction AT michaelwierer e47modulateshepaticglucocorticoidaction AT kristinaschachtrup e47modulateshepaticglucocorticoidaction AT michaeldownes e47modulateshepaticglucocorticoidaction AT norberthubner e47modulateshepaticglucocorticoidaction AT ronaldmevans e47modulateshepaticglucocorticoidaction AT nhenrietteuhlenhaut e47modulateshepaticglucocorticoidaction |
_version_ |
1718386560175439872 |