E47 modulates hepatic glucocorticoid action

E47 modulates hepatic glucocorticoid action

Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglyc...

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Main Authors: M. Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M. Evans, N. Henriette Uhlenhaut
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e
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spelling oai:doaj.org-article:c66a0d65c60642e39dc4efc1ae62484e2021-12-02T15:35:33ZE47 modulates hepatic glucocorticoid action10.1038/s41467-018-08196-52041-1723https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08196-5https://doaj.org/toc/2041-1723Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.M. Charlotte HemmerMichael WiererKristina SchachtrupMichael DownesNorbert HübnerRonald M. EvansN. Henriette UhlenhautNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
M. Charlotte Hemmer
Michael Wierer
Kristina Schachtrup
Michael Downes
Norbert Hübner
Ronald M. Evans
N. Henriette Uhlenhaut
E47 modulates hepatic glucocorticoid action
description Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and that loss of E47 protects mice from hyperglycemia and hepatic steatosis in response to GCs.
format article
author M. Charlotte Hemmer
Michael Wierer
Kristina Schachtrup
Michael Downes
Norbert Hübner
Ronald M. Evans
N. Henriette Uhlenhaut
author_facet M. Charlotte Hemmer
Michael Wierer
Kristina Schachtrup
Michael Downes
Norbert Hübner
Ronald M. Evans
N. Henriette Uhlenhaut
author_sort M. Charlotte Hemmer
title E47 modulates hepatic glucocorticoid action
title_short E47 modulates hepatic glucocorticoid action
title_full E47 modulates hepatic glucocorticoid action
title_fullStr E47 modulates hepatic glucocorticoid action
title_full_unstemmed E47 modulates hepatic glucocorticoid action
title_sort e47 modulates hepatic glucocorticoid action
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e
work_keys_str_mv AT mcharlottehemmer e47modulateshepaticglucocorticoidaction
AT michaelwierer e47modulateshepaticglucocorticoidaction
AT kristinaschachtrup e47modulateshepaticglucocorticoidaction
AT michaeldownes e47modulateshepaticglucocorticoidaction
AT norberthubner e47modulateshepaticglucocorticoidaction
AT ronaldmevans e47modulateshepaticglucocorticoidaction
AT nhenrietteuhlenhaut e47modulateshepaticglucocorticoidaction
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