NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.

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Auteurs principaux: Ge Qin, Xin Wang, Shubiao Ye, Yizhuo Li, Miao Chen, Shusen Wang, Tao Qin, Changlin Zhang, Yixin Li, Qian Long, Huabin Hu, Dingbo Shi, Jiaping Li, Kai Zhang, Qinglian Zhai, Yanlai Tang, Tiebang Kang, Ping Lan, Fangyun Xie, Jianjun Lu, Wuguo Deng
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
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Accès en ligne:https://doaj.org/article/c6acc872cde14c7396dd8715b3c6ef94
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Internet

https://doaj.org/article/c6acc872cde14c7396dd8715b3c6ef94

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