NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.

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Detalles Bibliográficos
Autores principales:	Ge Qin, Xin Wang, Shubiao Ye, Yizhuo Li, Miao Chen, Shusen Wang, Tao Qin, Changlin Zhang, Yixin Li, Qian Long, Huabin Hu, Dingbo Shi, Jiaping Li, Kai Zhang, Qinglian Zhai, Yanlai Tang, Tiebang Kang, Ping Lan, Fangyun Xie, Jianjun Lu, Wuguo Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6acc872cde14c7396dd8715b3c6ef94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c6acc872cde14c7396dd8715b3c6ef942021-12-02T14:41:15ZNPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer10.1038/s41467-020-15364-z2041-1723https://doaj.org/article/c6acc872cde14c7396dd8715b3c6ef942020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15364-zhttps://doaj.org/toc/2041-1723PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.Ge QinXin WangShubiao YeYizhuo LiMiao ChenShusen WangTao QinChanglin ZhangYixin LiQian LongHuabin HuDingbo ShiJiaping LiKai ZhangQinglian ZhaiYanlai TangTiebang KangPing LanFangyun XieJianjun LuWuguo DengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ge Qin Xin Wang Shubiao Ye Yizhuo Li Miao Chen Shusen Wang Tao Qin Changlin Zhang Yixin Li Qian Long Huabin Hu Dingbo Shi Jiaping Li Kai Zhang Qinglian Zhai Yanlai Tang Tiebang Kang Ping Lan Fangyun Xie Jianjun Lu Wuguo Deng NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
description	PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.
format	article
author	Ge Qin Xin Wang Shubiao Ye Yizhuo Li Miao Chen Shusen Wang Tao Qin Changlin Zhang Yixin Li Qian Long Huabin Hu Dingbo Shi Jiaping Li Kai Zhang Qinglian Zhai Yanlai Tang Tiebang Kang Ping Lan Fangyun Xie Jianjun Lu Wuguo Deng
author_facet	Ge Qin Xin Wang Shubiao Ye Yizhuo Li Miao Chen Shusen Wang Tao Qin Changlin Zhang Yixin Li Qian Long Huabin Hu Dingbo Shi Jiaping Li Kai Zhang Qinglian Zhai Yanlai Tang Tiebang Kang Ping Lan Fangyun Xie Jianjun Lu Wuguo Deng
author_sort	Ge Qin
title	NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
title_short	NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
title_full	NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
title_fullStr	NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
title_full_unstemmed	NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
title_sort	npm1 upregulates the transcription of pd-l1 and suppresses t cell activity in triple-negative breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c6acc872cde14c7396dd8715b3c6ef94
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NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

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