Synthetic cytokine receptors transmit biological signals using artificial ligands

Synthetic cytokine receptors transmit biological signals using artificial ligands

Cytokine-induced signaling acts as an ON/OFF switch dependent on the presence of ligands. Here the authors construct synthetic cytokine receptors responsive to synthetic ligands able to activate canonical signaling pathways.

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Autores principales: Erika Engelowski, Artur Schneider, Manuel Franke, Haifeng Xu, Ramona Clemen, Alexander Lang, Paul Baran, Christian Binsch, Birgit Knebel, Hadi Al-Hasani, Jens M. Moll, Doreen M. Floß, Philipp A. Lang, Jürgen Scheller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/c6eac6251dec4202873e73c5dcbf15f0
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spelling oai:doaj.org-article:c6eac6251dec4202873e73c5dcbf15f02021-12-02T17:31:46ZSynthetic cytokine receptors transmit biological signals using artificial ligands10.1038/s41467-018-04454-82041-1723https://doaj.org/article/c6eac6251dec4202873e73c5dcbf15f02018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04454-8https://doaj.org/toc/2041-1723Cytokine-induced signaling acts as an ON/OFF switch dependent on the presence of ligands. Here the authors construct synthetic cytokine receptors responsive to synthetic ligands able to activate canonical signaling pathways.Erika EngelowskiArtur SchneiderManuel FrankeHaifeng XuRamona ClemenAlexander LangPaul BaranChristian BinschBirgit KnebelHadi Al-HasaniJens M. MollDoreen M. FloßPhilipp A. LangJürgen SchellerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Erika Engelowski
Artur Schneider
Manuel Franke
Haifeng Xu
Ramona Clemen
Alexander Lang
Paul Baran
Christian Binsch
Birgit Knebel
Hadi Al-Hasani
Jens M. Moll
Doreen M. Floß
Philipp A. Lang
Jürgen Scheller
Synthetic cytokine receptors transmit biological signals using artificial ligands
description Cytokine-induced signaling acts as an ON/OFF switch dependent on the presence of ligands. Here the authors construct synthetic cytokine receptors responsive to synthetic ligands able to activate canonical signaling pathways.
format article
author Erika Engelowski
Artur Schneider
Manuel Franke
Haifeng Xu
Ramona Clemen
Alexander Lang
Paul Baran
Christian Binsch
Birgit Knebel
Hadi Al-Hasani
Jens M. Moll
Doreen M. Floß
Philipp A. Lang
Jürgen Scheller
author_facet Erika Engelowski
Artur Schneider
Manuel Franke
Haifeng Xu
Ramona Clemen
Alexander Lang
Paul Baran
Christian Binsch
Birgit Knebel
Hadi Al-Hasani
Jens M. Moll
Doreen M. Floß
Philipp A. Lang
Jürgen Scheller
author_sort Erika Engelowski
title Synthetic cytokine receptors transmit biological signals using artificial ligands
title_short Synthetic cytokine receptors transmit biological signals using artificial ligands
title_full Synthetic cytokine receptors transmit biological signals using artificial ligands
title_fullStr Synthetic cytokine receptors transmit biological signals using artificial ligands
title_full_unstemmed Synthetic cytokine receptors transmit biological signals using artificial ligands
title_sort synthetic cytokine receptors transmit biological signals using artificial ligands
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c6eac6251dec4202873e73c5dcbf15f0
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