A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to...

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Autores principales: S. N. Gettinger, J. Choi, N. Mani, M. F. Sanmamed, I. Datar, Ryan Sowell, Victor Y. Du, E. Kaftan, S. Goldberg, W. Dong, D. Zelterman, K. Politi, P. Kavathas, S. Kaech, X. Yu, H. Zhao, J. Schlessinger, R. Lifton, D. L. Rimm, L. Chen, R. S. Herbst, K. A. Schalper
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f1
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https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f1

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