A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to...

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Autores principales: S. N. Gettinger, J. Choi, N. Mani, M. F. Sanmamed, I. Datar, Ryan Sowell, Victor Y. Du, E. Kaftan, S. Goldberg, W. Dong, D. Zelterman, K. Politi, P. Kavathas, S. Kaech, X. Yu, H. Zhao, J. Schlessinger, R. Lifton, D. L. Rimm, L. Chen, R. S. Herbst, K. A. Schalper
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f1
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spelling oai:doaj.org-article:c6ec06496e454ad4bab2a7a08fce84f12021-12-02T15:33:38ZA dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers10.1038/s41467-018-05032-82041-1723https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f12018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05032-8https://doaj.org/toc/2041-1723Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to ICB.S. N. GettingerJ. ChoiN. ManiM. F. SanmamedI. DatarRyan SowellVictor Y. DuE. KaftanS. GoldbergW. DongD. ZeltermanK. PolitiP. KavathasS. KaechX. YuH. ZhaoJ. SchlessingerR. LiftonD. L. RimmL. ChenR. S. HerbstK. A. SchalperNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
S. N. Gettinger
J. Choi
N. Mani
M. F. Sanmamed
I. Datar
Ryan Sowell
Victor Y. Du
E. Kaftan
S. Goldberg
W. Dong
D. Zelterman
K. Politi
P. Kavathas
S. Kaech
X. Yu
H. Zhao
J. Schlessinger
R. Lifton
D. L. Rimm
L. Chen
R. S. Herbst
K. A. Schalper
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
description Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to ICB.
format article
author S. N. Gettinger
J. Choi
N. Mani
M. F. Sanmamed
I. Datar
Ryan Sowell
Victor Y. Du
E. Kaftan
S. Goldberg
W. Dong
D. Zelterman
K. Politi
P. Kavathas
S. Kaech
X. Yu
H. Zhao
J. Schlessinger
R. Lifton
D. L. Rimm
L. Chen
R. S. Herbst
K. A. Schalper
author_facet S. N. Gettinger
J. Choi
N. Mani
M. F. Sanmamed
I. Datar
Ryan Sowell
Victor Y. Du
E. Kaftan
S. Goldberg
W. Dong
D. Zelterman
K. Politi
P. Kavathas
S. Kaech
X. Yu
H. Zhao
J. Schlessinger
R. Lifton
D. L. Rimm
L. Chen
R. S. Herbst
K. A. Schalper
author_sort S. N. Gettinger
title A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
title_short A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
title_full A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
title_fullStr A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
title_full_unstemmed A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
title_sort dormant til phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c6ec06496e454ad4bab2a7a08fce84f1
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