Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and betwe...

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Autores principales: O. Shukron, V. Piras, D. Noordermeer, D. Holcman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c70071dba39f424aa41f561fbf358bb7
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