Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and betwe...

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Auteurs principaux:	O. Shukron, V. Piras, D. Noordermeer, D. Holcman
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c70071dba39f424aa41f561fbf358bb7
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spelling	oai:doaj.org-article:c70071dba39f424aa41f561fbf358bb72021-12-02T16:58:24ZStatistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers10.1038/s41467-019-10402-x2041-1723https://doaj.org/article/c70071dba39f424aa41f561fbf358bb72019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10402-xhttps://doaj.org/toc/2041-1723Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and between TADs and reconstruct TADs across cell differentiation, revealing local chromatin re-organization.O. ShukronV. PirasD. NoordermeerD. HolcmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q O. Shukron V. Piras D. Noordermeer D. Holcman Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
description	Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency encounters present in Hi-C data within and between TADs and reconstruct TADs across cell differentiation, revealing local chromatin re-organization.
format	article
author	O. Shukron V. Piras D. Noordermeer D. Holcman
author_facet	O. Shukron V. Piras D. Noordermeer D. Holcman
author_sort	O. Shukron
title	Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_short	Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_full	Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_fullStr	Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_full_unstemmed	Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
title_sort	statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c70071dba39f424aa41f561fbf358bb7
work_keys_str_mv	AT oshukron statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers AT vpiras statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers AT dnoordermeer statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers AT dholcman statisticsofchromatinorganizationduringcelldifferentiationrevealedbyheterogeneouscrosslinkedpolymers
_version_	1718382355107807232

Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

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