A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

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Autores principales:	Michael R. Bowl, Michelle M. Simon, Neil J. Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R. Bower, Dave A. Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, The International Mouse Phenotyping Consortium, Glauco P. Tocchini-Valentini, Xiang Gao, Allan Bradley, William C. Skarnes, Mark Moore, Arthur L. Beaudet, Monica J. Justice, John Seavitt, Mary E. Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M. J. Nutter, Ann M. Flenniken, Colin McKerlie, Stephen A. Murray, Karen L. Svenson, Robert E. Braun, David B. West, K. C. Kent Lloyd, David J. Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F. Meehan, Helen E. Parkinson, Lydia M. Teboul, Sara Wells, Karen P. Steel, Ann-Marie Mallon, Steve D. M. Brown
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c71478f2406844f6901b4df53eb1c02c
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spelling	oai:doaj.org-article:c71478f2406844f6901b4df53eb1c02c2021-12-02T15:37:03ZA large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction10.1038/s41467-017-00595-42041-1723https://doaj.org/article/c71478f2406844f6901b4df53eb1c02c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00595-4https://doaj.org/toc/2041-1723The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.Michael R. BowlMichelle M. SimonNeil J. InghamSimon GreenawayLuis SantosHeather CaterSarah TaylorJeremy MasonNatalja KurbatovaSelina PearsonLynette R. BowerDave A. ClaryHamid MezianePatrick ReillyOsamu MinowaLois KelseyThe International Mouse Phenotyping ConsortiumGlauco P. Tocchini-ValentiniXiang GaoAllan BradleyWilliam C. SkarnesMark MooreArthur L. BeaudetMonica J. JusticeJohn SeavittMary E. DickinsonWolfgang WurstMartin Hrabe de AngelisYann HeraultShigeharu WakanaLauryl M. J. NutterAnn M. FlennikenColin McKerlieStephen A. MurrayKaren L. SvensonRobert E. BraunDavid B. WestK. C. Kent LloydDavid J. AdamsJacqui WhiteNatasha KarpPaul FlicekDamian SmedleyTerrence F. MeehanHelen E. ParkinsonLydia M. TeboulSara WellsKaren P. SteelAnn-Marie MallonSteve D. M. BrownNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
description	The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.
format	article
author	Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown
author_facet	Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown
author_sort	Michael R. Bowl
title	A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
title_short	A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
title_full	A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
title_fullStr	A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
title_full_unstemmed	A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
title_sort	large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c71478f2406844f6901b4df53eb1c02c
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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

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