Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites

Meng-Hsuan Lin et al. investigate MERS-CoV macro domain binding selectivity with NAD and NAD metabolites under various conditions. At physiological temperature, NAD is observed to have enhanced binding affinity to the MERS-CoV macro domain, shedding light on a new possible role of the MERS-CoV macro...

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Bibliographic Details
Main Authors: Meng-Hsuan Lin, Chao-Cheng Cho, Yi-Chih Chiu, Chia-Yu Chien, Yi-Ping Huang, Chi-Fon Chang, Chun-Hua Hsu
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/c746f4f54dab40188dea1673f5a05a7b
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