Three-dimensional in situ morphometrics of Mycobacterium tuberculosis infection within lesions by optical mesoscopy and novel acid-fast staining

Abstract Tuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D measurements consider heterogeneity within a single...

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Autores principales: Robert J. Francis, Gillian Robb, Lee McCann, Bhagwati Khatri, James Keeble, Belinda Dagg, Brad Amos, Francisco J. Salguero, Mei Mei Ho, Anwen Bullen, Gail McConnell, Kirsty MacLellan-Gibson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c753bc9f75174c4195e6c28918b47a23
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