Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.

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Detalles Bibliográficos
Autores principales: Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/c77feaa169934783a5813a2d5609a475
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https://doaj.org/article/c77feaa169934783a5813a2d5609a475

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