Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.
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Nature Portfolio
2017
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oai:doaj.org-article:c77feaa169934783a5813a2d5609a4752021-12-02T15:38:37ZCardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling10.1038/s41467-017-01737-42041-1723https://doaj.org/article/c77feaa169934783a5813a2d5609a4752017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01737-4https://doaj.org/toc/2041-1723MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.Yassine SassiPetros AvramopoulosDeepak RamanujamLaurenz GrüterStanislas WerfelSimon GioseleAndreas-David BrunnerDena EsfandyariAikaterini S. PapadopoulouBart De StrooperNorbert HübnerRegalla KumarswamyThomas ThumXiaoke YinManuel MayrBernhard LaggerbauerStefan EngelhardtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yassine Sassi Petros Avramopoulos Deepak Ramanujam Laurenz Grüter Stanislas Werfel Simon Giosele Andreas-David Brunner Dena Esfandyari Aikaterini S. Papadopoulou Bart De Strooper Norbert Hübner Regalla Kumarswamy Thomas Thum Xiaoke Yin Manuel Mayr Bernhard Laggerbauer Stefan Engelhardt Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| description |
MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes. |
| format |
article |
| author |
Yassine Sassi Petros Avramopoulos Deepak Ramanujam Laurenz Grüter Stanislas Werfel Simon Giosele Andreas-David Brunner Dena Esfandyari Aikaterini S. Papadopoulou Bart De Strooper Norbert Hübner Regalla Kumarswamy Thomas Thum Xiaoke Yin Manuel Mayr Bernhard Laggerbauer Stefan Engelhardt |
| author_facet |
Yassine Sassi Petros Avramopoulos Deepak Ramanujam Laurenz Grüter Stanislas Werfel Simon Giosele Andreas-David Brunner Dena Esfandyari Aikaterini S. Papadopoulou Bart De Strooper Norbert Hübner Regalla Kumarswamy Thomas Thum Xiaoke Yin Manuel Mayr Bernhard Laggerbauer Stefan Engelhardt |
| author_sort |
Yassine Sassi |
| title |
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| title_short |
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| title_full |
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| title_fullStr |
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| title_full_unstemmed |
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling |
| title_sort |
cardiac myocyte mir-29 promotes pathological remodeling of the heart by activating wnt signaling |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c77feaa169934783a5813a2d5609a475 |
| work_keys_str_mv |
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