The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, c...

Full description

Saved in:
Bibliographic Details
Main Authors: Kiranmai Gumireddy, Anping Li, Andrew V. Kossenkov, Masayuki Sakurai, Jinchun Yan, Yan Li, Hua Xu, Jian Wang, Paul J. Zhang, Lin Zhang, Louise C. Showe, Kazuko Nishikura, Qihong Huang
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Q
Online Access:https://doaj.org/article/c7b601a345de4fb581ae27dae1f787e0
Tags: Add Tag
No Tags, Be the first to tag this record!