The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, c...

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Autores principales:	Kiranmai Gumireddy, Anping Li, Andrew V. Kossenkov, Masayuki Sakurai, Jinchun Yan, Yan Li, Hua Xu, Jian Wang, Paul J. Zhang, Lin Zhang, Louise C. Showe, Kazuko Nishikura, Qihong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7b601a345de4fb581ae27dae1f787e0
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spelling	oai:doaj.org-article:c7b601a345de4fb581ae27dae1f787e02021-12-02T15:34:11ZThe mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis10.1038/ncomms107152041-1723https://doaj.org/article/c7b601a345de4fb581ae27dae1f787e02016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10715https://doaj.org/toc/2041-1723GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, can suppress the function of wild type GABRA3.Kiranmai GumireddyAnping LiAndrew V. KossenkovMasayuki SakuraiJinchun YanYan LiHua XuJian WangPaul J. ZhangLin ZhangLouise C. ShoweKazuko NishikuraQihong HuangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kiranmai Gumireddy Anping Li Andrew V. Kossenkov Masayuki Sakurai Jinchun Yan Yan Li Hua Xu Jian Wang Paul J. Zhang Lin Zhang Louise C. Showe Kazuko Nishikura Qihong Huang The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
description	GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, can suppress the function of wild type GABRA3.
format	article
author	Kiranmai Gumireddy Anping Li Andrew V. Kossenkov Masayuki Sakurai Jinchun Yan Yan Li Hua Xu Jian Wang Paul J. Zhang Lin Zhang Louise C. Showe Kazuko Nishikura Qihong Huang
author_facet	Kiranmai Gumireddy Anping Li Andrew V. Kossenkov Masayuki Sakurai Jinchun Yan Yan Li Hua Xu Jian Wang Paul J. Zhang Lin Zhang Louise C. Showe Kazuko Nishikura Qihong Huang
author_sort	Kiranmai Gumireddy
title	The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
title_short	The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
title_full	The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
title_fullStr	The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
title_full_unstemmed	The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
title_sort	mrna-edited form of gabra3 suppresses gabra3-mediated akt activation and breast cancer metastasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c7b601a345de4fb581ae27dae1f787e0
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The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

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