Single-Cell RNA-Seq Analysis Reveals the Acquisition of Cancer Stem Cell Traits and Increase of Cell–Cell Signaling during EMT Progression

Single-Cell RNA-Seq Analysis Reveals the Acquisition of Cancer Stem Cell Traits and Increase of Cell–Cell Signaling during EMT Progression

Intermediate cell states (ICSs) during the epithelial–mesenchymal transition (EMT) are emerging as a driving force of cancer invasion and metastasis. ICSs typically exhibit hybrid epithelial/mesenchymal characteristics as well as cancer stem cell (CSC) traits including proliferation and drug resista...

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Detalles Bibliográficos
Autores principales: Federico Bocci, Peijie Zhou, Qing Nie
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
EMT
cancer stem cells
cell–cell signaling
scRNA-seq
epithelial–mesenchymal plasticity
hybrid E/M
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/c7fc6915883b4b429d859f6f56a7b82b
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https://doaj.org/article/c7fc6915883b4b429d859f6f56a7b82b

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