An in vitro platform for engineering and harnessing modular polyketide synthases

A robust platform to study modular polyketide synthases (PKSs) in vitro is still unavailable. Here, the authors report the reconstitution of the venemycin PKS, engineer hybrid venemycin/pikromycin PKSs, and obtain much improved yields through employing the updated module boundaries.

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Autores principales: Takeshi Miyazawa, Melissa Hirsch, Zhicheng Zhang, Adrian T. Keatinge-Clay
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c81b22727cf3473480de12de0e456449
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