A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

In many AMPylating FIC proteins a structurally conserved glutamate represses AMPylation. Here, the authors show that this glutamate supports deAMPylation in Enterococcus faecalis FIC (EfFIC), and that EfFIC switches from AMPylation to deAMPylation by binding Ca2+ at distinct sites.

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Autores principales: Simon Veyron, Giulia Oliva, Monica Rolando, Carmen Buchrieser, Gérald Peyroche, Jacqueline Cherfils
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c82bc1c01f6d4d08a41f42155b940323
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