A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

In many AMPylating FIC proteins a structurally conserved glutamate represses AMPylation. Here, the authors show that this glutamate supports deAMPylation in Enterococcus faecalis FIC (EfFIC), and that EfFIC switches from AMPylation to deAMPylation by binding Ca2+ at distinct sites.

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Autores principales:	Simon Veyron, Giulia Oliva, Monica Rolando, Carmen Buchrieser, Gérald Peyroche, Jacqueline Cherfils
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c82bc1c01f6d4d08a41f42155b940323
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spelling	oai:doaj.org-article:c82bc1c01f6d4d08a41f42155b9403232021-12-02T16:58:16ZA Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins10.1038/s41467-019-09023-12041-1723https://doaj.org/article/c82bc1c01f6d4d08a41f42155b9403232019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09023-1https://doaj.org/toc/2041-1723In many AMPylating FIC proteins a structurally conserved glutamate represses AMPylation. Here, the authors show that this glutamate supports deAMPylation in Enterococcus faecalis FIC (EfFIC), and that EfFIC switches from AMPylation to deAMPylation by binding Ca2+ at distinct sites.Simon VeyronGiulia OlivaMonica RolandoCarmen BuchrieserGérald PeyrocheJacqueline CherfilsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Veyron Giulia Oliva Monica Rolando Carmen Buchrieser Gérald Peyroche Jacqueline Cherfils A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
description	In many AMPylating FIC proteins a structurally conserved glutamate represses AMPylation. Here, the authors show that this glutamate supports deAMPylation in Enterococcus faecalis FIC (EfFIC), and that EfFIC switches from AMPylation to deAMPylation by binding Ca2+ at distinct sites.
format	article
author	Simon Veyron Giulia Oliva Monica Rolando Carmen Buchrieser Gérald Peyroche Jacqueline Cherfils
author_facet	Simon Veyron Giulia Oliva Monica Rolando Carmen Buchrieser Gérald Peyroche Jacqueline Cherfils
author_sort	Simon Veyron
title	A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
title_short	A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
title_full	A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
title_fullStr	A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
title_full_unstemmed	A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
title_sort	ca2+-regulated deampylation switch in human and bacterial fic proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c82bc1c01f6d4d08a41f42155b940323
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A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

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