Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi Met immediately before transition into elongation...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c83cad0e29c9428c8c5db019de2b15ba |
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| Sumario: | The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi Met immediately before transition into elongation, providing insight on Met-tRNAi Metdelivery and how the correct reading frame is established. |
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