Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex

The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi Met immediately before transition into elongation...

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Autores principales:	Jinfan Wang, Jing Wang, Byung-Sik Shin, Joo-Ran Kim, Thomas E. Dever, Joseph D. Puglisi, Israel S. Fernández
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c83cad0e29c9428c8c5db019de2b15ba
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spelling	oai:doaj.org-article:c83cad0e29c9428c8c5db019de2b15ba2021-12-02T16:57:09ZStructural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex10.1038/s41467-020-18829-32041-1723https://doaj.org/article/c83cad0e29c9428c8c5db019de2b15ba2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18829-3https://doaj.org/toc/2041-1723The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi Met immediately before transition into elongation, providing insight on Met-tRNAi Metdelivery and how the correct reading frame is established.Jinfan WangJing WangByung-Sik ShinJoo-Ran KimThomas E. DeverJoseph D. PuglisiIsrael S. FernándezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinfan Wang Jing Wang Byung-Sik Shin Joo-Ran Kim Thomas E. Dever Joseph D. Puglisi Israel S. Fernández Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
description	The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAi Me t on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAi Met immediately before transition into elongation, providing insight on Met-tRNAi Metdelivery and how the correct reading frame is established.
format	article
author	Jinfan Wang Jing Wang Byung-Sik Shin Joo-Ran Kim Thomas E. Dever Joseph D. Puglisi Israel S. Fernández
author_facet	Jinfan Wang Jing Wang Byung-Sik Shin Joo-Ran Kim Thomas E. Dever Joseph D. Puglisi Israel S. Fernández
author_sort	Jinfan Wang
title	Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
title_short	Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
title_full	Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
title_fullStr	Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
title_full_unstemmed	Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex
title_sort	structural basis for the transition from translation initiation to elongation by an 80s-eif5b complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c83cad0e29c9428c8c5db019de2b15ba
work_keys_str_mv	AT jinfanwang structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT jingwang structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT byungsikshin structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT joorankim structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT thomasedever structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT josephdpuglisi structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex AT israelsfernandez structuralbasisforthetransitionfromtranslationinitiationtoelongationbyan80seif5bcomplex
_version_	1718382646905536512

Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex

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