Differential effects of SUMO1 and SUMO2 on circadian protein PER2 stability and function

Abstract Posttranslational modification (PTM) of core circadian clock proteins, including Period2 (PER2), is required for proper circadian regulation. PER2 function is regulated by casein kinase 1 (CK1)-mediated phosphorylation and ubiquitination but little is known about other PER2 PTMs or their in...

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Autores principales: Ling-Chih Chen, Yung-Lin Hsieh, Grace Y. T. Tan, Tai-Yun Kuo, Yu-Chi Chou, Pang-Hung Hsu, Wendy W. Hwang-Verslues
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c8703bfb39e34a1f8846b341bee43c82
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