Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats
Abstract The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaem...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c8af6294593b4984a956202d64d9b81a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c8af6294593b4984a956202d64d9b81a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c8af6294593b4984a956202d64d9b81a2021-12-02T15:02:31ZRole of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats10.1038/s41598-021-91228-w2045-2322https://doaj.org/article/c8af6294593b4984a956202d64d9b81a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91228-whttps://doaj.org/toc/2045-2322Abstract The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaemia. Therefore, the present study was aimed to search for metabolic responses of fed or fasted male rats to a single EMF exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT, intensity) EMF, and determined serum levels of glucose, lipids, and indicators of cellular redox state and energy parameters. A single exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups, and an attenuated second serum insulin peak. The 60-Hz EMF also decreased free fatty acids and lactate serum levels, oppositely increasing pyruvate and acetoacetate levels. Significant increases in blood glucose level and rat’s glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. The 60-Hz EMF’s effects were not modified in animals previously subjected to chronic EMFs exposure (14 days). In conclusion, increased serum glucose levels and glucose metabolism induced by a single 60-Hz EMF exposure were closely related to the cellular redox state and the insulin/glucagon ratio.Gabriel Martiñón-GutiérrezMaría Luna-CastroRolando Hernández-MuñozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Gabriel Martiñón-Gutiérrez María Luna-Castro Rolando Hernández-Muñoz Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| description |
Abstract The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaemia. Therefore, the present study was aimed to search for metabolic responses of fed or fasted male rats to a single EMF exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT, intensity) EMF, and determined serum levels of glucose, lipids, and indicators of cellular redox state and energy parameters. A single exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups, and an attenuated second serum insulin peak. The 60-Hz EMF also decreased free fatty acids and lactate serum levels, oppositely increasing pyruvate and acetoacetate levels. Significant increases in blood glucose level and rat’s glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. The 60-Hz EMF’s effects were not modified in animals previously subjected to chronic EMFs exposure (14 days). In conclusion, increased serum glucose levels and glucose metabolism induced by a single 60-Hz EMF exposure were closely related to the cellular redox state and the insulin/glucagon ratio. |
| format |
article |
| author |
Gabriel Martiñón-Gutiérrez María Luna-Castro Rolando Hernández-Muñoz |
| author_facet |
Gabriel Martiñón-Gutiérrez María Luna-Castro Rolando Hernández-Muñoz |
| author_sort |
Gabriel Martiñón-Gutiérrez |
| title |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| title_short |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| title_full |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| title_fullStr |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| title_full_unstemmed |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats |
| title_sort |
role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-hz magnetic field in rats |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c8af6294593b4984a956202d64d9b81a |
| work_keys_str_mv |
AT gabrielmartinongutierrez roleofinsulinglucagonratioandcellredoxstateinthehyperglycaemiainducedbyexposuretoa60hzmagneticfieldinrats AT marialunacastro roleofinsulinglucagonratioandcellredoxstateinthehyperglycaemiainducedbyexposuretoa60hzmagneticfieldinrats AT rolandohernandezmunoz roleofinsulinglucagonratioandcellredoxstateinthehyperglycaemiainducedbyexposuretoa60hzmagneticfieldinrats |
| _version_ |
1718389103670591488 |