GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

Summary: Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic role of the isoform GABAB1e (GB1e) containing only...

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Autores principales:	Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang, Jianfeng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Molecular biology Neuroscience Science Q
Acceso en línea:	https://doaj.org/article/c8be0a9624c74e0fa5a997cc31a09980
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spelling	oai:doaj.org-article:c8be0a9624c74e0fa5a997cc31a099802021-11-20T05:09:48ZGABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN122589-004210.1016/j.isci.2021.103311https://doaj.org/article/c8be0a9624c74e0fa5a997cc31a099802021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012803https://doaj.org/toc/2589-0042Summary: Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic role of the isoform GABAB1e (GB1e) containing only the extracellular domain of GABAB1 remains unclear. We revealed that GB1e is largely expressed in human breast cancer (BrCa) cell lines as well as in BrCa tissues where it is upregulated. Moreover, GB1e promoted the malignancy of BrCa cells both in vitro and in vivo. We propose that GB1e favors EGFR signaling by interacting with PTPN12 to disrupt the interaction between EGFR and PTPN12, and phosphorylation of Y230 and Y404 on GB1e is required in this process. Our data highlight that the GABBR1 gene through the expression of the GB1e isoform might play an important oncogenic role in BrCa and that GB1e is of interest for the treatment of some cancers.Bo WeiYini ZhuPeng YangYong HanSuyun WangXiaomei WangShuai XiaXiaoguang SongZhongling ZhangSheng WangPhilippe RondardJean-Philippe PinXinnong JiangJianfeng LiuElsevierarticleBiological sciencesMolecular biologyNeuroscienceScienceQENiScience, Vol 24, Iss 11, Pp 103311- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Molecular biology Neuroscience Science Q
spellingShingle	Biological sciences Molecular biology Neuroscience Science Q Bo Wei Yini Zhu Peng Yang Yong Han Suyun Wang Xiaomei Wang Shuai Xia Xiaoguang Song Zhongling Zhang Sheng Wang Philippe Rondard Jean-Philippe Pin Xinnong Jiang Jianfeng Liu GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
description	Summary: Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic role of the isoform GABAB1e (GB1e) containing only the extracellular domain of GABAB1 remains unclear. We revealed that GB1e is largely expressed in human breast cancer (BrCa) cell lines as well as in BrCa tissues where it is upregulated. Moreover, GB1e promoted the malignancy of BrCa cells both in vitro and in vivo. We propose that GB1e favors EGFR signaling by interacting with PTPN12 to disrupt the interaction between EGFR and PTPN12, and phosphorylation of Y230 and Y404 on GB1e is required in this process. Our data highlight that the GABBR1 gene through the expression of the GB1e isoform might play an important oncogenic role in BrCa and that GB1e is of interest for the treatment of some cancers.
format	article
author	Bo Wei Yini Zhu Peng Yang Yong Han Suyun Wang Xiaomei Wang Shuai Xia Xiaoguang Song Zhongling Zhang Sheng Wang Philippe Rondard Jean-Philippe Pin Xinnong Jiang Jianfeng Liu
author_facet	Bo Wei Yini Zhu Peng Yang Yong Han Suyun Wang Xiaomei Wang Shuai Xia Xiaoguang Song Zhongling Zhang Sheng Wang Philippe Rondard Jean-Philippe Pin Xinnong Jiang Jianfeng Liu
author_sort	Bo Wei
title	GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
title_short	GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
title_full	GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
title_fullStr	GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
title_full_unstemmed	GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
title_sort	gabab1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase ptpn12
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c8be0a9624c74e0fa5a997cc31a09980
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_version_	1718419567280128000

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

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