Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and identified positive and inverse cross-cancer associatio...

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Autores principales:	Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee8
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spelling	oai:doaj.org-article:c8c7f06feddc43b4892e0628726c8ee82021-12-02T14:11:09ZCross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts10.1038/s41467-021-21288-z2041-1723https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21288-zhttps://doaj.org/toc/2041-1723While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and identified positive and inverse cross-cancer associations.Rebecca E. GraffTaylor B. CavazosKhanh K. ThaiLinda KachuriSara R. RashkinJoshua D. HoffmanStacey E. AlexeeffMaruta BlatchinsTravis J. MeyersLancelote LeongCaroline G. TaiNima C. EmamiDouglas A. CorleyLawrence H. KushiElad ZivStephen K. Van Den EedenEric JorgensonThomas J. HoffmannLaurel A. HabelJohn S. WitteLori C. SakodaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca E. Graff Taylor B. Cavazos Khanh K. Thai Linda Kachuri Sara R. Rashkin Joshua D. Hoffman Stacey E. Alexeeff Maruta Blatchins Travis J. Meyers Lancelote Leong Caroline G. Tai Nima C. Emami Douglas A. Corley Lawrence H. Kushi Elad Ziv Stephen K. Van Den Eeden Eric Jorgenson Thomas J. Hoffmann Laurel A. Habel John S. Witte Lori C. Sakoda Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
description	While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and identified positive and inverse cross-cancer associations.
format	article
author	Rebecca E. Graff Taylor B. Cavazos Khanh K. Thai Linda Kachuri Sara R. Rashkin Joshua D. Hoffman Stacey E. Alexeeff Maruta Blatchins Travis J. Meyers Lancelote Leong Caroline G. Tai Nima C. Emami Douglas A. Corley Lawrence H. Kushi Elad Ziv Stephen K. Van Den Eeden Eric Jorgenson Thomas J. Hoffmann Laurel A. Habel John S. Witte Lori C. Sakoda
author_facet	Rebecca E. Graff Taylor B. Cavazos Khanh K. Thai Linda Kachuri Sara R. Rashkin Joshua D. Hoffman Stacey E. Alexeeff Maruta Blatchins Travis J. Meyers Lancelote Leong Caroline G. Tai Nima C. Emami Douglas A. Corley Lawrence H. Kushi Elad Ziv Stephen K. Van Den Eeden Eric Jorgenson Thomas J. Hoffmann Laurel A. Habel John S. Witte Lori C. Sakoda
author_sort	Rebecca E. Graff
title	Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
title_short	Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
title_full	Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
title_fullStr	Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
title_full_unstemmed	Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
title_sort	cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee8
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Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

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