Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway

Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway

Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor immunity. While several studies have demonstrated iNKT cell cytotoxicity against different tumors, very little is known about their cell‐killing a...

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Bibliographic Details
Main Authors: Angélica Díaz‐Basabe, Claudia Burrello, Georgia Lattanzi, Fiorenzo Botti, Alberto Carrara, Elisa Cassinotti, Flavio Caprioli, Federica Facciotti
Format: article
Language:EN
Published: Wiley 2021
Subjects:
CD1d
colorectal cancer
cytotoxicity
iNKT
perforin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/c8cd6bf6609248f79a02e8de99757ec0
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https://doaj.org/article/c8cd6bf6609248f79a02e8de99757ec0

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