Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.

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Detalles Bibliográficos
Autores principales: Atsushi Yamagata, Yuri Miyazaki, Norihiko Yokoi, Hideki Shigematsu, Yusuke Sato, Sakurako Goto-Ito, Asami Maeda, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Mikako Shirouzu, Yuko Fukata, Masaki Fukata, Shuya Fukai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/c8d56a79c67b43399c581db013e3959e
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https://doaj.org/article/c8d56a79c67b43399c581db013e3959e

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