Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.

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Autores principales: Atsushi Yamagata, Yuri Miyazaki, Norihiko Yokoi, Hideki Shigematsu, Yusuke Sato, Sakurako Goto-Ito, Asami Maeda, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Mikako Shirouzu, Yuko Fukata, Masaki Fukata, Shuya Fukai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c8d56a79c67b43399c581db013e3959e
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spelling oai:doaj.org-article:c8d56a79c67b43399c581db013e3959e2021-12-02T15:34:03ZStructural basis of epilepsy-related ligand–receptor complex LGI1–ADAM2210.1038/s41467-018-03947-w2041-1723https://doaj.org/article/c8d56a79c67b43399c581db013e3959e2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03947-whttps://doaj.org/toc/2041-1723LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.Atsushi YamagataYuri MiyazakiNorihiko YokoiHideki ShigematsuYusuke SatoSakurako Goto-ItoAsami MaedaTeppei GotoMakoto SanboMasumi HirabayashiMikako ShirouzuYuko FukataMasaki FukataShuya FukaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Atsushi Yamagata
Yuri Miyazaki
Norihiko Yokoi
Hideki Shigematsu
Yusuke Sato
Sakurako Goto-Ito
Asami Maeda
Teppei Goto
Makoto Sanbo
Masumi Hirabayashi
Mikako Shirouzu
Yuko Fukata
Masaki Fukata
Shuya Fukai
Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
description LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.
format article
author Atsushi Yamagata
Yuri Miyazaki
Norihiko Yokoi
Hideki Shigematsu
Yusuke Sato
Sakurako Goto-Ito
Asami Maeda
Teppei Goto
Makoto Sanbo
Masumi Hirabayashi
Mikako Shirouzu
Yuko Fukata
Masaki Fukata
Shuya Fukai
author_facet Atsushi Yamagata
Yuri Miyazaki
Norihiko Yokoi
Hideki Shigematsu
Yusuke Sato
Sakurako Goto-Ito
Asami Maeda
Teppei Goto
Makoto Sanbo
Masumi Hirabayashi
Mikako Shirouzu
Yuko Fukata
Masaki Fukata
Shuya Fukai
author_sort Atsushi Yamagata
title Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
title_short Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
title_full Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
title_fullStr Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
title_full_unstemmed Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
title_sort structural basis of epilepsy-related ligand–receptor complex lgi1–adam22
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c8d56a79c67b43399c581db013e3959e
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