Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2018
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/c8d56a79c67b43399c581db013e3959e |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|