CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation.

CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation.

Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(+) T cells with elevated levels of markers fo...

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Main Authors: Tobias Ruck, Stefan Bittner, Catharina C Gross, Johanna Breuer, Stefanie Albrecht, Sabrina Korr, Kerstin Göbel, Susann Pankratz, Christian M Henschel, Nicholas Schwab, Ori Staszewski, Marco Prinz, Tanja Kuhlmann, Sven G Meuth, Heinz Wiendl
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/c8ebb82be39e4f35b7810c9fc93cb3c9
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