miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury

miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury

Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy by targeting small mitochondrial alternative reading frame (smARF) for...

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Bibliographic Details
Main Authors: Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G.R. Scott Budinger, Jing Liu
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
JNK2
sepsis
lung inflammation and injury
micro RNA (miRNA)
smARF
ubiquitination and degradation
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/c8ed6666624b4fa99b7c46a6cb604a90
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https://doaj.org/article/c8ed6666624b4fa99b7c46a6cb604a90

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