Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota

Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-ga...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junyue Xing, Yongquan Ying, Chenxi Mao, Yiwei Liu, Tingting Wang, Qian Zhao, Xiaoling Zhang, Fuxia Yan, Hao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8fff85f72c84720a26d9d33ef0b27dd
record_format	dspace
spelling	oai:doaj.org-article:c8fff85f72c84720a26d9d33ef0b27dd2021-12-02T16:49:18ZHypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota10.1038/s41467-018-04453-92041-1723https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04453-9https://doaj.org/toc/2041-1723Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-galactose accumulation.Junyue XingYongquan YingChenxi MaoYiwei LiuTingting WangQian ZhaoXiaoling ZhangFuxia YanHao ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junyue Xing Yongquan Ying Chenxi Mao Yiwei Liu Tingting Wang Qian Zhao Xiaoling Zhang Fuxia Yan Hao Zhang Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
description	Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-galactose accumulation.
format	article
author	Junyue Xing Yongquan Ying Chenxi Mao Yiwei Liu Tingting Wang Qian Zhao Xiaoling Zhang Fuxia Yan Hao Zhang
author_facet	Junyue Xing Yongquan Ying Chenxi Mao Yiwei Liu Tingting Wang Qian Zhao Xiaoling Zhang Fuxia Yan Hao Zhang
author_sort	Junyue Xing
title	Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_short	Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_full	Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_fullStr	Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_full_unstemmed	Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_sort	hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd
work_keys_str_mv	AT junyuexing hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT yongquanying hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT chenximao hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT yiweiliu hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT tingtingwang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT qianzhao hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT xiaolingzhang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT fuxiayan hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota AT haozhang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
_version_	1718383361762787328

Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota

Ejemplares similares